UCL (University College London) is one of UK’s premier universities and a world-class research and teaching institution based in London with an annual turnover approaching £500 million and involvement in more than 400 EU-funded research collaborations; a world-class multidisciplinary research and teaching institution, whose staff and former students have included 19 Nobel Prize winners. Founded in 1826, UCL was the first university in England to admit students regardless of race, religion or gender. It continues to thrive on the creativity and diversity of its community which today comprises 8,000 staff, and 12,000 undergraduates and 7,000 graduate students from 130 countries across the globe.
In partnership with Great Ormond Street Hospital and as part of UCL, the Institute of Child Health is the leading British academic research institution for child health and has an international reputation in many areas of child health including epilepsy research. Examples of external recognition for our work include the maximum Grade 5*A that was awarded to ICH in the 2001 HEFCE Research Assessment Exercise, one of only four in clinical sciences. The epilepsy research programme within this unit has an international reputation with an extensive output of publications and high success rate in obtaining external peer-reviewed funding. It is currently also involved as a partner in the European project EPICURE and in EUROPED.
The UCL Elizabeth Garrett Anderson Institute for Women’s Health, a joint venture between two world-renowned institutions, University College London (UCL) and University College London Hospital (UCLH) brings together individuals with expertise across the whole spectrum of women’s health from maternal and fetal medicine to clinical skills to social and behavioural sciences, both in the UK and internationally, by pioneering research, education programmes and clinical initiatives.
University College London Hospital (UCLH) has a large level III perinatal centre with a specific interest in perinatal brain injury.
Principal Investigator: Janet Rennie
Dr Janet Rennie is a Consultant Neonatologist with a special interest in brain injury in babies and a Principal Investigator in the Wellcome Trust funded ANSeR Clinical Investigation.
Dr Rennie was a Lecturer in Paediatrics, University of Cambridge from 1985-to 1987, and held a Consultant appointment in Cambridge until 1995. Whilst in Cambridge she was also Director of Medical Studies at Girton College. Dr Rennie held an appointment as Consultant in Neonatal Medicine at King’s College Hospital in London from 1995 to 2004 and now holds a similar post at University College London Hospitals where she is the Clinical Lead in Neonatology. She has contributed chapters to the major British textbook of paediatrics and many other books, and co-authored “Manual of Neonatal Intensive Care 4th Edition” with Dr NRC Roberton. She is the editor of “Rennie & Roberton’s Textbook of Neonatology 5th Edition”, and also the Editor of the 4th edition. Dr Rennie was also the sole author of “Neonatal Cranial Ultrasound”, and co-author of the updated version entitled “Neonatal Cerebral Investigation” (highly commended in the BMA Book Prize 2009 and by Doody’s Book Reviews). Dr Rennie was elected a Fellow ad eundem of the Royal College of Obstetricians and Gynaecologists in 2008.
Dr Rennie is involved in research into neonatal brain injury, and has published many papers on this topic. The NBRG currently holds a Wellcome technology transfer grant, for work on automated seizure detection, and Dr Rennies is also a co-investigator in a European study (FP-7) of antiepileptic drug treatment of neonatal seizures: NEMO. She was on the board of the Archives of Disease in Childhood for ten years and served on the national executive committee of the British Association of Perinatal Medicine for a similar length of time. She currently serves on the board of the Mac Keith Press and was the Chair of the RCPCH Specialist Advisory Committee, responsible for setting standards regarding training in neonatal medicine in the UK, from 2002 to 2005, having been on the committee since 1997. She has advised CESDI, and RCOG-led advisory groups on “Safer Childbirth” and “Standards for Maternity Care” and was Chair of the NICE guideline development group on neonatal jaundice 2007-10.
ANSeR Research Fellow: Sean Matheson
The ANSeR program. Output of the algorithm is a graph of the probability of seizure (upper blue trace) which turns red when a predefined threshold is breeched and a seizure is designated.
The focus of research at UCL (Sean Mathieson) is analyzing the performance of ANSeR from a neurophysiological perspective including: the characteristics of detected and non-detected seizures, the effect of phenobarbitone on seizure morphology and on the performance of ANSeR and also whether the use of ANSeR improves drug treatment times.